Epidemiological Factors and Pathomorphologic Characteristics of Hydatidiform Mole

Abstract

Introduction: Hydatidiform mole is a gestational trophoblastic disease characterized by a range of disorders of abnormal trophoblastic proliferation.
Methods: This was a retrospective study of 70 singletone pregnancies until the 12th week of gestational age diagnosed with hydatidiform mole or spontaneously aborted physiological pregnancy. The pregnant
women had almost similar demographic features and were divided into two groups. 35 pregnant women with a molar pregnancy were included in the study group; while 35 pregnant women with physiological
pregnancy spontaneously aborted were included in the control group. Analyzed parameters included a pregnant woman’s age, blood type, parity and previous pregnancies (course and outcomes).
Results: In the study group 11.43% of cases had hydatidiform mola during previous pregnancies as well as the advanced average gestational age of an ongoing pregnancy (9.63±1.83 in contrast to 8.25±2.03
in the control group). The pregnant women with the hydatidiform mole were reported to have statistically significantly greater number of irregular villous borders (71.43%); slightly enlarged villi (54.29%); moderated
presence of cisterns (65.71%) as well as mild avascularisation of villi (57.14%).
Conclusion: It was concluded that a previous molar pregnancy represents the highest risk for hydtidiforme mole and the pathomorphologic analysis of vilous changes can be a reliable parameter for establishing
proper diagnosis of partial hydatidiform mole.